Genetic pathways that control cardiac embryogenesis follows intricate temporal patterns. Concept of first and second heart fields, a population of potent cardiac cells that initiate the simple heart tube, has been deciphered. Role of genes and various controlling factors in multiplex regulatory systems that drive organogenesis that is altered in disease needs to recognised and is one of the greatest challenges in science. Understanding and control of these steps may lead to a revolution in auto engineered artificial organs and targeted therapy of congenital heart disease and early detection of these lesions.
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