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Biography

PROF RADHAKRISHNAN PRADEEP KUMAR

MS, MCh CTVS AIIMS,Post doctoral Fellow CTVS (SCTIMST),Post doctoral Fellow in ECMO

(International Simulation Society & International Society of Cardiovascular Ultrasound), FACC,FIACS,Global MBA Lond,CPDH IISc

Current Designation

Vice Chairman AMTZ-IC-SCR

Mentor World Innovation Hub

 

Professor and Honorary Consultant

Travancore Heart Institute 

Professor and Chief Division of CTVS,

Program Coordinator Total Artificial Heart and MCS

09-08-2019 - 31-07-2022

GIMSR, Gitam University, Visakhapatnam,

AP India 530045

Higher Training :

Visitor Physician Mayo Clinic Rochester USA

International Observer Boston Children's Hospital USA

Additional Degrees/Fellowships :

Innovations:  HEC Paris

Thoracic Oncology: University of Michigan USA

Honors in Transplantation: Leiden University Netherlands & South Africa

Anatomy :  University  Michigan USA,

Public Health: Imperial College London

Biomedical Visualization : Glasgow UK

Immunology: Rice University USA

Physiology : Rice University

Radiation : University of Sydney

 

Reviewer : 

ISHLT, Cureus-Magna Reviewer

Editor :

MMTS and E Chronicon Cardiology, JAMSR,IJSR,GJRA

Society Memberships - National & International :

STS, IACTS, EACTS, ISMICS,ELSO,ESOI,ACC,AHA,HFSA,ISHLT

INSHLT,ISCP ISCVE,IMA,CTSNET,HFAI, ISCVP

Member International Relationship Committee

2021-2022 HFSA (USA)

Work Experience:

Jr Resident SSIHMS Puttaparthi 1991-1993

Sr Resident AIIMS New Delhi 1998-2000 

Fellow SCTIMST - 2001

Senior Consultant and Coordinator KIMS 2001-2103, Visiting Senior Consultant PRS Group, SUT Pattom & SUT Royal Group 2008-2013,

Associate Professor  Travancore Heart Institute Travancore Medical College and Hospital 2013-2018

Senior Consultant AHRI 2018-2019

Professor of Cardiac Surgery GIMSR 2019- onwards

Education & Training

2021

Fellow Of American College Of 

Cardiology-FACC

2020

Global MBA Lond., Fellow Of Indian Association Of Cardiothoracic Surgeons, CPDH Indian Institute of Science

2001,2019

Fellowship, Cardiothoracic and Vascular Surgery-SCTIMST, Fellowship in ECMO-International Simulation Society

1998

MCh CTVS AIIMS New Delhi India

Research Publications

- 2021, Publication Title -

Nanoscale Flow Choking and Spaceflight Effects on Cardiovascular Risk of Astronauts – A New Perspective American Institute of Aerronautics and Astronautics 2021

Abstract

Of late, authors reported conclusively through the state-of-the-art closed-form analytical methodology that the asymptomatic stroke and the transient-ischemic-attack could occur due to the Sanal flow choking (PMCID: PMC7267099). Sanal flow choking leads to the shock wave generation causing arterial stiffening in the arteries particularly with bifurcation regions. At the internal flow choking (biofluid/Sanal flow choking) condition, the systolic-to-diastolic blood pressure ratio (BPR) is a unique function of the blood/biofluid heat capacity ratio (BHCR). The physical situation of internal flow choking in the micro/nanoscale fluid flows in the circulatory system is more susceptible at microgravity condition due to altered variations of blood viscosity, turbulence and the BPR. During a long-term space mission, the major factor that affects cardiovascular dysfunctions is the absence of gravity. Note that microgravity environment decreases plasma volume and increases the hematocrit compared with the situation on the earth surface, which increases the relative viscosity of blood. Since blood viscosity strongly depends on hematocrit there are possibilities of an early Sanal flow choking in microgravity environment due to an enhanced boundary layer blockage. While using the lopsided blood-thinners and/or drugs with anticoagulant property, the dynamic viscosity of blood decreases and as a result Reynolds number increases and the laminar flow could be disrupted and become turbulent and thereby the boundary-layer-blockage factor increases leading to an early internal flow choking. As the pressure of the nanoscale biofluid flows rises, average-mean-free-path diminishes and thus, the Knudsen number lowers heading to a zero-slip wall-boundary condition with compressible viscous flow effect, which increases the risk of internal flow choking in the cardiovascular system at gravity and the microgravity environment. In this paper analytical, in vitro and in silico results are reported to establish the concept of the occurrence of Sanal flow choking in the gravity and micro gravity environment in micro/nanoscale circulatory systems. We could establish herein that the relatively high and the low blood-viscosity are cardiovascular risk factors during the spaceflight. We concluded that for a healthy-life all subjects (human being / animals) in the earth and in the outer space with high BPR necessarily have high BHCR. We also concluded that for reducing the cardiovascular risk, all the astronauts/cosmonauts should maintain the BPR lower than the lower critical hemorrhage index (LCHI) as dictated by the lowest heat capacity ratio (HCR) of the gas generating from the biofluid/blood for prohibiting the internal flow choking during the space travel. We recommend all astronauts/cosmonauts should wear ambulatory blood pressure and thermal level monitoring devices similar to a wristwatch throughout the space travel for the diagnosis, prognosis and prevention of internal flow choking leading to asymptomatic cardiovascular diseases. We concluded without any ex vivo or in vivo studies that suppressing the turbulence level and simultaneously reducing the blood viscosity are the key tasks to prevent internal flow choking for reducing the cardiovascular risk in earth as well as in microgravity conditions. This could be achieved by increasing the thermal tolerance level of blood by increasing the heat capacity ratio of blood and/or decreasing blood pressure ratio 

- 2021, Publication Title -

EMERGING GAMUT OF CARDIOVASCULAR NANOMEDICINE: FUTURE IS BRIGHT

Abstract

The aim of cardiovascular nanomedicine- CVN is to reduce off-target toxicity issues with therapeutic selectivity to the heart .The lipophilic barrier of the cellular membranes should be circumvented to deliver cargo inside the cell. Lipid based NPs, which show low side effects and greater ability to passively accumulate at tissues with higher vascular permeability (enhanced permeation rate), have been largely used since the earlier times of cardiovascular nanomedicine-CVN. Polymeric NPs, silica NPs, carbon nanotubes, polymeric micelles, quantum dots, nano fibers and nanocrystals represent other examples of nano-formulations for controlled drug delivery. NP-loaded drugs are expected to be protected from systemic degradation, show reduced toxicity and immunogenicity, possess ameliorated pharmacokinetics and increased half-life and exhibit increased bioavailability and precise bio distribution. Nanodrug formulations are expected to enhance selective delivery to the site of interest and benefit from a lower clearance from the body. Nanotechnology represents a convergent discipline in which the margins separating research areas, such as chemistry, biology, physics, mathematics and engineering become blurred with the much needed emergence of integrated science as a new discipline.

Awards

2021

Gitam Bhatnagar Research Award- 2021 Best Medical Research

Nanoscale Flow Choking and Spaceflight Effects on Cardiovascular Risk of Astronauts – A New Perspective

National Science Day 2021

2021

Leben Johnson Award  National Smartideathon 2021- Best Innovative Idea- Radically Orchestrated Surgical Instruments by AI enablement( ROSAI)