CARDIAC ORGANOIDS - ADVANCED PLATFORMS FOR DISEASE MODELLING,DRUG SCREENING, AND TRANSLATIONAL CARDIAC REGENERATION

VOLUME - 15, ISSUE - 03, MARCH - 2026 • PRINT ISSN No. 2277 - 8160

DOI : 10.36106/gjra

ABSTRACT - Cardiovascular diseases (CVDs) remain the leading cause of global mortality. Traditional 2D

cardiomyocyte cultures and animal models fail to fully replicate human-specic cardiac morphogenesis,

electrophysiology, and drug responses. Cardiac organoids (COs), including self-organizing cardioids, represent a

transformative 3D in vitro system capable of recapitulating chamber morphogenesis, multi-lineage interactions, and functional

contractility. Recent innovations in chamber-specic differentiation, decellularized extracellular matrix (dECM) scaffolding, AIdriven

contractility quantication, and volumetric 3D bioprinting have substantially enhanced translational potential. This

review synthesizes state-of-the-art methodologies and outlines pre-clinical and regulatory considerations for rst-in-human

applications.

https://www.worldwidejournals.com/global-journal-for-research-analysis-GJRA/recent_issues_pdf/2026/March/cardiac-organoids--advanced-platforms-for-disease-modelling-drug-screening-and-translational-cardiac-regeneration_March_2026_4397911777_6200464.pdf